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Published 2008-05-15 16:20:00
 


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Column By Authors of the IOM Report On Medical Marijuana
Shows Why The Public Does Not Trust The Medical Establishment –
And Why They Should Not! With Analysis by Richard Cowan


(Marijuananews note: I had been hoping that the authors of the IOM report would offer some commentary on their work now that they are free from the restrictions of their mandate.
See
Executive Summary Of The IOM Report, Marijuana And Medicine: Assessing The Science Base
and the full text at
http://www.drugsense.org/iom_report

First, there were some seeming ambiguities in the report that needed clarifying.

Second, there is the nasty business of the actual policies of the DEAland government, arresting patients, threatening doctors and suppressing research.

I was wondering what they would have to say about these subjects. I am still wondering, and their ambiguities turned out to be the inevitable products of absurdity. This is a major moral and intellectual scandal.

It means little to the actual debate on medical marijuana, but it should be of great concern to those who care about intellectual and scientific standards in medicine.

When the IOM report was first issued, I said that "Only in a public discourse as debased as that surrounding marijuana could something as mediocre as the Institute of Medicine Medical Marijuana report have such an impact."

See
Will The Titanic Of Marijuana Prohibition Be Sunk By The Ice Cube Of The IOM Report?
-- Analysis.

and links

After reading the column below, I have concluded that "mediocre" was really too generous a term.

One of the great things about writing on computers and communicating on the Internet is that it is possible to dissect a work sentence by sentence. Sadly it is sometimes necessary to do that. This is such a case.

What is truly bizarre about this column is that they sometimes seem to be misrepresenting their own work!)

April 13, 1999
From The Standard-Times
Copyright: 1999 The Standard-Times
YourView@S-T.com
http://www.s-t.com/

(Marijuananews note: The Standard-Times is a relatively small Massachusetts paper, so I assume that this column will appear in many other papers around the country and will be cited by prohibitionists.

Because of the extensive comments I have printed all of the original in Red, and all emphasis is added. Quotes from the IOM report itself are in green italics.)

By John A. Benson Jr., Stanley J. Watson Jr.
(John A. Benson Jr. is dean and professor of medicine emeritus at the Oregon Health Sciences University School of Medicine, Portland. Stanley J. Watson Jr. is co-director and research scientist at the Mental Health Research Institute, University of Michigan, Ann Arbor. They were co-principal investigators of the Institute of Medicine’s study on the medical use of marijuana.)

STRIKE A BALANCE IN THE MARIJUANA DEBATE

Everyone seemed to declare victory when a study on the medical use of marijuana was issued last month.

(Marijuananews note: In fact, NORML was very critical of the report, as was MarijuanaNews.)
See
NORML Special Bulletin -- IOM Acknowledges:
"There is no clear alternative for people suffering from chronic conditions
that might be relieved by smoking marijuana, such as pain or AIDS wasting."
But Still Opposes Smoked Marijuana --

Advocates for legalizing such use said the report aided their cause by concluding that the compounds in marijuana do have some potential as medicine.

(Marijuananews note: No, that was not the reason cited by any anti-prohibitionists that I have seen. As Benson and Watson note, the "compounds in marijuana" are widely recognized as having medical value. THC is already available by prescription. That did not aid our cause.

Rather, the report was welcomed for two reasons. First, it demolished some of the silliest prohibitionist arguments, such as the "gateway theory." It even reported, "During the 1990s, marijuana use has continued to increase in the Netherlands at the same rate as in the United States and Norway two countries that strictly forbid marijuana sale and possession. Further, during this period, approximately equal percentages of American and Dutch 18-year olds used marijuana… In sum, there is little evidence that decriminalization of marijuana use necessarily leads to a substantial increase in marijuana use." Section 3. Page 26

As I said, it made a much better case for legalizing marijuana than for medical marijuana. That was an unexpected dividend.

Second, it also said that there are people for whom nothing else seems to work.
"Until a non-smoked, rapid-onset cannabinoid drug delivery system becomes available, we acknowledge that there is no clear alternative for people suffering from chronic conditions that might be relieved by smoking marijuana, such as pain or AIDS wasting." From page 9 of the Executive Summary.

That is really more than is necessary to validate making anything medically available, and that is all that the advocates of medical marijuana have been saying, while the prohibitionists have been saying that marijuana is totally unnecessary. It is a typical prohibitionist tactic to misrepresent the anti-prohibitionist position.)

Their opponents, on the other hand, cheered the report’s conclusion that the harmful effects of smoking far outweigh potential benefits for most patients. In reality, both sides are right.

(Marijuananews note: In reality, no. The Drug Czar himself said that there was "not shred of evidence" that marijuana has medical value. Are Benson and Watson trying to cover up for the Czar? Maybe they are trying to get a job at The Washington Post. Even granting the anti-smoking argument, the point is still that there are patients for whom nothing else works and for whom using marijuana is worth taking almost any risk – including arrest, which they don’t mention. But more on that later.)

The study—which we led for the Institute of Medicine—firmly concluded that the active compounds in marijuana do have potential as medicine. But that future does not involve smoking.
(Marijuananews note: Perhaps, but what about the present? The prospect of better treatments in the future has never been cited as justifying letting a patient suffer and die in any other circumstance.)

Scientific hair-splitting? Hardly. To date it has been nearly impossible to separate scientific evidence about marijuana’s potential from larger societal concerns about its use.

(Marijuananews note: And whose fault is that? Have the advocates of medical marijuana been blocking research? In any case, why would it be impossible to separate a controversy about social policy from scientific data? In the end, their own report refuted or dismissed as irrelevant the prohibitionists’ non-medical arguments against medical marijuana.)

But doing so may be the key needed to advance the rancorous debate that has engulfed this issue since medical marijuana began to appear on state ballot initiatives in the mid-1990s.
(Marijuananews note: Oh, did the debate not begin until it appeared on the ballot? Or was dissent ignored until the initiatives forced the government to find a new way to stall, using people like Benson and Watson?)

Those who have followed the debate may be surprised to learn that in the scientific realm, we found remarkable consensus that marijuana’s components have potential to relieve symptoms such as pain, nausea and vomiting, and the poor appetite associated with wasting in AIDS or cancer.
(Marijuananews note: On the contrary, anyone who has been following the debate would know that the prohibitionists claim that THC is already available and therefore medical marijuana is unnecessary. Also, if someone was really paying attention they would know about the discovery of other cannabinoids -- often outside of DEAland.)
See
Marijuana Appears To Protect Against Brain Injuries, Federal Researchers Find
and
Cannabis May Prevent Brain Damage From Strokes; Slow Progress of Alzheimers and Parkinsonism
DEAland National Institute of Mental Health Study, But Reported In British Media

and
Marijuana Derivative Blocks Irreversible Brain Damage After Accidents; Another Way Marijuana Prohibition Kills

For most symptoms there are more effective drugs already on the market, but physicians encounter patients who do not respond well to standard medications, or who need additional therapies. These patients could benefit from new drugs based on cannabinoids, the active components in marijuana.
(Marijuananews note: Notice that the first sentence is in the present tense, "need additional therapies." Notice then that the second sentence is in the conditional, "could benefit from new drugs" – which could maybe possibly be developed sometime perhaps at an unknown time in the indeterminate future. The report says,
"The critical issue is not whether marijuana or cannabinoid drugs might be superior to the new drugs, but rather whether there is a group of patients who might obtain added or better relief from marijuana or cannabinoid drugs." The IOM report also says "even with the best antiemetic drugs, the control of nausea and vomiting that begins or persists 24 hours after chemotherapy remains imperfect." Section 4 page 16.

In other words, the report makes clear that present medications do not relieve suffering in a wide range of cases, but here we are told only that the patients "could benefit from new drugs." They should live so long, if they can bear the pain. They could benefit from marijuana right now!)

Marijuana’s future as medicine rests in developing new ways of delivering these cannabinoids—including the most common one, THC.

(Marijuananews note: The IOM report completely ignores vaporization, as well as ingestion. I know that Dr. Grinspoon specifically told them about vaporizers, but it is hardly a secret. Why did they not even mention studying vaporizers? Was it because the ready availability of vaporizers would vaporize their only excuse for adhering to the prohibitionist party line?)

Presently there is only one such drug on the market. Marinol, a THC capsule, is approved by the Food and Drug Administration for treatment of nausea and vomiting associated with chemotherapy, as well as poor appetite and weight loss associated with AIDS.
See
Gettman Petition For Hearings On Marinol Rescheduling Uses DEA’s Own Arguments Against It.
Why Marinol Is Not Medical Marijuana. Wonderfully Brilliant!

However, some who have used Marinol complain that it takes effect slowly, and its results are variable. Sufferers of pain, nausea and vomiting obviously need fast-acting medication.

(Marijuananews note: If "Sufferers of pain, nausea and vomiting obviously need fast-acting medication," then don’t they need fast-acting policies? Are present sufferers supposed to wait for years until a politically correct way of delivering cannabinoids is developed in the future? Their callousness is damned by their own statement.)

For that reason, we recommend that clinical trials move forward with the goal of developing a rapid-onset, non-smoked delivery system, such as an inhaler. This type of device could deliver precise doses without the health problems associated with smoking.

Admittedly, an inhaler could take years to produce. What do we do right now?

In deciding whether marijuana should be smoked as medicine, society must weigh the reality of this crude drug-delivery system against the benefits it might bestow.

(Marijuananews note: "Society must weigh the reality of this crude drug-delivery system against the benefits it might bestow." What a curious statement in this context! In reality, that is precisely what has been going on in the medical marijuana initiatives. "Society has weighed the reality" and an overwhelming majority of the people have rejected the advice of the medical establishment, the prohibitionist leadership of DEAland, and often the very biased media, and have decided that it is wrong to arrest sick people for using a plant that helps them. They know these numbers: "Public support for patient access to marijuana for medical use appears substantial; public opinion polls taken during 1997 and 1998 generally report 60-70 percent of respondents in favor of allowing medical uses of marijuana." Section 1 page 6.)
See
Gallup Poll Shows 73% Favor Medical Marijuana;
29% Favor Outright "Legalization"!
So What Are The Politicians Really Afraid Of?

Chronic smoking of marijuana increases a person’s chances of developing cancer, lung damage, and problems with pregnancies, including low birth weight. Therefore, it simply is not an acceptable long-term option.

(Marijuananews note: Perhaps, but as their own report says, "proof that habitual marijuana smoking does or does not cause cancer awaits the results of well-designed studies." The same applies to other risks.

And why in so short an article did they feel compelled to warn about "problems with pregnancies, including low birth weight." Their own report says, "although fertility and fetal development are important concerns for many, they are unlikely to be of much concern to people with seriously debilitating or life-threatening diseases." Section 3 page 46

And remember, Thalidomide is now available by prescription.
See
Marijuana, Caffeine, Thalidomide and the Persecution of the Sick and Dying

It is plausible that long-term heavy "smoking of marijuana increases a person’s chances of developing" health problems, but there is still no proof that it does.

Indeed, there are large populations of long-term heavy smokers, but there is no data that indicate that they are having serious health problems. Of course, this does not mean that these problems will not emerge in the future.

Second, most medical marijuana users do not use large quantities of smoke, and whatever risks that may exist are almost certainly dose related. For example, many people with chronic nausea only need to smoke a small amount three or four times a day. Also the "potent pot" that the prohibitionists like to warn us about would require less smoking than the marijuana that the government currently supplies to the eight legal users.

Third, those who need to smoke more may find the risk worth taking for two reasons. Other drugs may simply not work, or they may have debilitating side-effects, a point that is largely ignored here. And, sadly, while their present condition may not be "terminal", their actual life expectancy may be substantially below the average. The "long-term" risks are not of such great relevance, particularly in the face of present suffering.)

Smoking should be allowed only for short-term use among patients with debilitating symptoms, or who are terminally ill and do not respond well to approved medications.
(Marijuananews note: Now here is where it gets nasty. "Smoking should be allowed only for short-term use." "Allowed"? All right, doctors, then what is to be the punishment for using it when you would not allow it?

Having said the magic word, "allow", they can no longer pretend that they have nothing to say about the use of the criminal law to persecute patients. I did not raise this point in commenting on the IOM report, because it was supposedly beyond their task. However, even the report does not say that "Smoking should be allowed only for short-term use" in so many words.

It merely said that "trials should involve only short-term marijuana use (less than six months); be conducted in patients with conditions for which there is reasonable expectation of efficacy; be approved by institutional review boards; and collect data about efficacy." They are thus going beyond what the report itself said.

In commenting on this section, I said that "There are two major problems with this. First, what happens to the patients after six months? Are they just going to be left to suffer? Or is this really just a way of recommending a six-month review period? If it is the former, it is absurd, unethical and cruel. If it is the second, it is really clever."

It is now clear that they really meant that the patients are just going to be left to suffer, and this really is absurd, unethical and cruel. It is absurd, because no one is going to agree to this.

Imagine that the patient and the doctor have found something that alleviates the patient’s suffering for six months, then the doctor has to say that the patient can’t have it anymore because of some unproven long-term risk. That would be unethical for the doctor and beyond cruel as a policy.

I should also have said that it is arbitrary and completely unscientific.

There is no basis for the six-month limit. Why not nine months? Or six years, three months and four days? If the patient is being closely monitored, why is any arbitrary time limit necessary? If there are problems with the marijuana use, then weigh the risks and benefits for the individual patient. This is what is done with other medications.

Their recommendation is bad science and worse medicine.

Of course, in the real world a patient who knows that marijuana works better than the alternatives will do everything possible to get it on the black market, which is where most patients are getting it now -- even in states with medical marijuana laws.

Again, this is where the question about the criminal laws has to be answered. The doctor and the patient will have six months clinical experience with marijuana and will know that marijuana works better than any legal drugs.

The patient will have to break the law. The doctor may be complicit in this by writing a "recommendation" to a buyers club.

Benson and Watson have said that this cannot be "allowed." They must now state the penalty.

But they dig themselves in deeper.)

Even in these cases, marijuana use should be limited to carefully controlled settings. Patients who are prescribed marijuana should be enrolled in short-term clinical trials that are approved by an oversight strategy such as institutional review boards, and involve only those patients most likely to benefit. They should be fully informed that they are experimental subjects and are using a harmful drug-delivery system, and their condition should be closely monitored and documented under medical supervision.

(Marijuananews note: No, they should be fully informed that they are the victims of a bad public policy. Patients should always be informed of risks, but what should they be told in this case. That there is a long-term risk? What is the relevance of this warning in a six-month trial? It has no relevance at all!

Why should they be experimental subjects, unless they are going to be "allowed" to continue to use the substance that is proven to help them? If it does not help them, then they will discontinue its use.)

These clinical trials of smoked marijuana should not be designed to develop it as a licensed drug, but should be a stepping stone to the development of new, safe delivery systems of cannabinoids.
(Marijuananews note: In fact, such limited trials would be of no value in developing such a "delivery system." Would injecting or ingesting a drug for six months help develop a new delivery system? This is a really puzzling statement.)

There is no evidence that using marijuana in controlled settings—or cannabinoids in the form of drugs such as Marinol—will lead to increased illicit drug use throughout society.

(Marijuananews note: Obviously I agree, but this sentence seems oddly placed. The whole subject is really irrelevant. Why did they throw it in here?)

Our review of the science behind marijuana and cannabinoids convinces us that the debate so far has been miscast. Rather than focusing on drug control policy, the medical marijuana debate should really be about the promise of future drug development.

(Marijuananews note: First, I don’t see any evidence that they know what the debate is really all about. They avoid the subject of arresting the sick and dying.

Second, my review of the subject convinces me that we should focus on alleviating the suffering of the sick, dying and disabled. I foolishly thought that this was the purpose of medicine. Now I find out that the patients are merely guinea pigs to be used for "the promise of future drug development." Silly me!)

Mining the pharmaceutical promise of cannabinoids will require the same kind of drug development that brought us any number of pain-killing drugs prescribed by physicians today. With public investments in research, or enough incentives to convince private companies to develop these drugs, the perceived need to smoke marijuana to alleviate symptoms could vanish.


(Marijuananews note: Happily, that is the end of their column. However, it is hardly clear why the "perceived need to smoke marijuana to alleviate symptoms could vanish."

What the hell does that mean? If a patient is vomiting or writhing in pain, will he feel better if we tell him that there are now "public incentives" –subsidies – for the pharmaceutical industry to develop expensive derivatives from cannabis? Would he no longer "perceive" that he was vomiting or in pain?

That statement is insulting to the suffering, which at this point would also include the reader of this drivel.

There are three additional points that should be made at this juncture:

First, one of the "Tasks" of the report was to evaluate "the costs of using various forms of marijuana versus approved drugs for specific medical conditions." This point was completely ignored in the column above.

Oddly, the section quoted below is also the only reference to the use of the criminal law to suppress medical marijuana. It is treated as a "cost." Maybe that is the only way they could sneak it in.

"During the IOM public workshops held during the course of this study, many people commented that an important advantage of using marijuana for medical purposes is that it is much less expensive than Marinol®. But this comparison is deceptive. While the direct costs of marijuana are relatively low, the indirect costs can be prohibitive. Individuals who violate federal or state marijuana laws risk a variety of costs associated with engaging in criminal activity, ranging from increased vulnerability to theft and personal injury legal fees to long prison terms. In addition, when purchasing illicit drugs there is no guarantee that the product purchased is what the seller claims it is, or that it is not contaminated.

The price of Marinol® for its most commonly used indication, anorexia in AIDS, is estimated at $200 dollars per month. The less commonly used indication -- nausea and vomiting with cancer chemotherapy -- is not as costly because use is not chronic. Yet regardless of indication, patients' out-of-pocket expenses tend to be much less, often minimal, because of reimbursement through public or private health insurance. For indigent patients who are uninsured, Roxane sponsors a patient assistance program to defray the cost.

The street value of marijuana is, according to DEA's most recent figures, about $5-10 per bag of loose plant  ( The DEA did not provide an estimate for the weight of marijuana per bag.)

At the California buyers' clubs, the price ranges from 2-16 dollars per gram, depending on the grade of marijuana. The cost to a patient using marijuana will vary according to the number of cigarettes smoked on a daily basis, their THC content, and the duration of use. Insurance does not cover the cost of marijuana. In addition, it is possible for a person to cultivate marijuana privately with little financial investment.
Thus, MARINOL® appears to be cheaper than marijuana for patients with health insurance or with financial assistance from Roxane. Yet' if the full cost of Marinol® is borne out-of-pocket by the patient, the cost comparison is not so unambiguous. In this case, the daily cost in relation to marijuana varies according to the number of cigarettes smoked: If the patient smokes two or more marijuana cigarettes a day, Marinol® may be cheaper than marijuana; if the patient smokes only one marijuana cigarette a day, dronabinol may be more expensive than marijuana, according to an analysis submitted to the DEA by Unimed. These cost comparisons will vary according to fluctuations in the retail price and street value of dronabinol and marijuana, respectively, and will vary if marijuana were to become commercially available." Section 5. Page 16

At no point does the above column consider that there are tens of millions of Americans who do not have health insurance and many millions more who are under-insured.

Second, for some reason the IOM report does not discuss the existing Compassionate Use program even though it includes a brief statement by one of the eight legal patients. I consider this to be the most inexcusable and inexplicable ommission, along with ignoring vaporizers.

The Compassionate Use program may have been ignroed because several of the legal eight are glaucoma patients. The report relied on prohibitionists Kaufman and Green and for most of their information on glaucoma, and so denied marijuana’s utility for its treatment. Therefore the program did not exist??
See
There Are None So Blind As Ophthalmologists Who Don’t Want to See:
Marijuana, Glaucoma, Science And Journalism -- Analysis -- And 3 News Articles

Finally, the report has the following statement:
"November 1998, the British House of Lords Science and Technology Committee published, Medical Use of Cannabis, in which they reported their conviction that "cannabis almost certainly does have genuine medical applications." The House of Lords report was released too late in the preparation of the IOM report to permit careful analysis, and is not summarized here."
See
Chairman of the House of Lords Science and Technology Committee
Criticizes UK Government’s Rejection Of Report On Medical Marijuana
– 2 Articles With 2 of the Worst Prohibitionist Arguments

The IOM report was issued over four months after the Lords report, but they say that they did not have time for "careful analysis." In fact, the above quote greatly understates the conclusions of the House of Lords report. Its very distinguished committee recommended that marijuana be rescheduled so that doctors could prescribe it now. Would it really have taken four months to accurately report what it said?

Also, the Finnish Medical Association endorsed medical marijuana in October. But they don’t even mention that. I reported, but they couldn’t find out about it?
See
Finnish Medical Association Supports Medical Marijuana
And Says Its Negative Effects Have Been Greatly Exaggerated.

In one section the IOM report says "Primum non nocere. This is the physician's first rule: whatever treatment a physician prescribes to a patient - first, that treatment must not harm the patient."

Judging by what we have seen here, I think that they have broken that rule. It is a shame and a scandal.

 
 

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